Colvasone Injection 50 ml (single injection)

Colvasone Injection 50 ml (single injection)
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Dexamethasone is a synthetic corticosteroid with a highly potent anti-inflammatory action. Colvasone can be used for:1. Intravenous therapy in cases where emergency treatment is indicated, particularly shock and circulatory collapse, fog fever, acute mastitis and burns.2. Acetonaemia (ketosis) in cattle.... Read more
Colvasone Injection 50 ml (single injection)

Dexamethasone is a synthetic corticosteroid with a highly potent anti-inflammatory action. Colvasone can be used for:
1. Intravenous therapy in cases where emergency treatment is indicated, particularly shock and circulatory collapse, fog fever, acute mastitis and burns.
2. Acetonaemia (ketosis) in cattle. Colvasone has a marked glucogenic action.
3. Inflammatory conditions in all species: Colvasone will suppress inflammation and is indicated in the treatment of arthritis, laminitis (excluding horses), dermatitis, etc.

Visit www.myvetmeds.co.uk / cat / steroids-cat / colvasone-injection-50-ml.htm

Product Description

About Colvasone Injection 50 ml (single injection)

Colvasone Injection 50 ml (single injection)

Dexamethasone is a synthetic corticosteroid with a highly potent anti-inflammatory action. Colvasone can be used for:
1. Intravenous therapy in cases where emergency treatment is indicated, particularly shock and circulatory collapse, fog fever, acute mastitis and burns.
2. Acetonaemia (ketosis) in cattle. Colvasone has a marked glucogenic action.
3. Inflammatory conditions in all species: Colvasone will suppress inflammation and is indicated in the treatment of arthritis, laminitis (excluding horses), dermatitis, etc.

Please note: images are for illustration purposes only and pack sizes/strengths and new packaging styles may not be reflected in the image shown.

Directions For Use

Directions for Use

By intravenous or intramuscular injection.
Normal aseptic precautions should be observed.
Dosage:
Horses and cattle: 1 ml per 25 kg bodyweight
Dogs and cats: 1 ml per 10 kg bodyweight
e.g.
Horses 500 kg - 20 ml
Cattle 400 kg - 16 ml
Dogs 10 kg - 1 ml
Cats 5 kg - 0.5 ml

To ensure accuracy of dosing, a suitably graduated syringe should be used when treating small animals.

Active Ingredient

Colvasone Injection 50 ml (single injection) ingredients

A sterile solution for injection containing Dexamethasone Sodium Phosphate Ph.Eur 2mg per ml, and Benzyl Alcohol Ph.Eur 20 mg per ml as preservative.

Side Effects

Side effects of Colvasone Injection 50 ml (single injection)

Cattle must not be slaughtered for human consumption during treatment. Cattle may be slaughtered for human consumption only after 21 days from the last treatment. Milk must not be taken for human consumption during treatment. Milk for human consumption may be taken from cows only from 72 hours after the last treatment.
Do not use in horses intended for human consumption.
Care should be taken to avoid accidental self-injection.
Systemic corticosteroid therapy is generally contra-indicated in patients with renal disease and diabetes mellitus.

Anti-inflammatory corticosteroids, such as dexamethasone, are known to exert a wide range of side-effects. Whilst single high doses are generally well tolerated, they may induce severe side-effects in long term use and when esters possessing a long duration of action are administered. Dosage in medium to long term use should therefore generally be kept to the minimum necessary to control symptoms.
Steroids themselves, during treatment, may cause Cushingoid symptoms involving significant alteration of fat, carbohydrate, protein and mineral metabolism, e.g. redistribution of body fat, muscle weakness and wastage and osteoporosis may result. During therapy effective doses suppress the Hypothalamo-Pituitreal-Adrenal axis. Following cessation of treatment, symptoms of adrenal insufficiency extending to adrenocorticol atrophy can arise and this may render the animal unable to deal adequately with stressful situations. Consideration should therefore be given to means of minimising problems of adrenal insufficiency following the withdrawal of treatment, e.g. a gradual reduction of dosage (for further discussion see standard texts).

Systemically acting corticosteroids may cause polyuria, polydipsia and polyphagia, particularly during the early stages of therapy. Some corticosteroids may cause sodium and water retention and hypokalaemia in long term use.

Systemic corticosteroids have caused deposition of calcium in the skin (calcinosis cutis).

Corticosteroids are not recommended for use in pregnant animals. Administration in early pregnancy is known to have caused foetal abnormalities in laboratory animals. Administration in late pregnancy may cause early parturition or abortion.

Corticosteroids may delay wound healing and the immunosuppressant actions may weaken resistance to or exacerbate existing infections. In the presence of bacterial infection, anti-bacterial drug cover is usually required when steroids are used. In the presence of viral infections, steroids may worsen or hasten the progress of the disease.

Gastrointestinal ulceration has been reported in animals treated with corticosteroids and g.i.t. ulceration may be exacerbated by steroids in patients given non-steroidal anti-inflammatory drugs and in corticosteroid-treated animals with spinal cord trauma. Steroids may cause enlargement of the liver (hepatomegaly) with increased serum hepatic enzymes.

Use of the product in horses could induce laminitis and therefore careful observations during treatment should be made.

During a course of treatment the situation should be reviewed frequently by close veterinary supervision.

Additional Data

Colvasone Injection 50 ml (single injection) specification

Specification: Detail:
Pack Size: single injection
Brands: Norbrook Laboratories
Product Form: injection
External Link: http://www.norbrook.co.uk/products/ProductData.cfm/product_Key/443/CatKey/1/Section/Veterinary_Products/
Strength/Size: 50 ml

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Q & A

Q. Thank you for your reply yesterday confirming that the recommended dose of colvasone 50ml for a 1.75kg cat would be 0.175 ml. Could you please let me know what the possible reaction/side effects would be if a frail 18 year old cat of 1.75 kg was given a 1 ml dose (one ml).

Many thanks

Ian Gibbons
A.

There are some conditions where a higher dose is used (shock doses, autoimmune diseases etc) - however, (obviously) I can't tell you which it is! I would advise you to contact your vet and discuss the dose.
Side effects from high doses of steroids typically include increased drinking and urination, and appetite; and increased susceptibility to infections.

David Harris BVSc MRCVS
MyVetMeds

Q. Hello could you please let me know what the recommend dose of Colvasone injection 50 ml would be for a cat weighing 1.75kg.

Many thanks

Ian gibbons
A.

The standard dose would be 0.175ml, by intravenous or intramuscular injection.

David Harris BVSc MRCVS
MyVetMeds

Q. is colvasone toxic to a dogs body
A.

Colvasone is a medicine, and like all medicines it has a variety of potential effects, good and bad.
Remember, EVERYTHING (sugars, fats, proteins, drugs, even water and oxygen) are toxic in the wrong amounts!
If you're concerned about side effects, you should speak to your vet, who will only prescribe any medicine if they feel that the beneficial effects will outweigh the potential risks.

David Harris BVSc MRCVS
MyVetMeds

Q. what does echogenic mean
A.

It refers to the appearance of a tissue on ultrasound.

David Harris BVSc MRCVS
MyVetMeds

Q. is 38.4c a fever in dogs
A.

No - normal temperature is in the range 38.0-38.8, roughly, depending on age, breed etc.

David Harris BVSc MRCVS
MyVetMeds

Q. can too much glycogen raise the ALT level in dogs
A.

ALT in dogs can be raised by liver damage, myocarditis (inflammation of the heart), fever, and some drugs; glucocorticoids like Colvasone are one medicine that can increase the ALT a little, but there are other causes too.

David Harris BVSc MRCVS
MyVetMeds

Q. is colvasone injecctions hard on the liver
A.

Corticosteroid injections have a wide range of side effects, but liver problems aren't common.

David Harris BVSc MRCVS
MyVetMeds

Q. my dog who weighs 35kg was given a single dose of 25ml colvasone for a swollen leg. she was on trocoxil 75mg tablets long term for arthritis. she died 4 days later after vomiting and heavy panting. vet said she had heart failure, do you think the steroid played a part in her death? She was 9and half years and i'm very heart-broken!
A.

I'm really sorry to hear about your dog. I'm afraid that it wouldn't be possible to tell whether the steroid injection was part of the cause without a post-mortem examination - however, if she died of heart failure, then it is very unlikely that it was a significant factor. Steroids are anti-inflammatory and have a wide range of side effects, but heart problems per se aren't recognised as a known issue.

David Harris BVSc MRCVS
MyVetMeds

Q. does a dexamethasone injection have less side effects than dexamethasone tablets
A.

As far as I'm aware, there aren't any dexamethasone tablets licensed for veterinary use in UK. The drug most normally used in tablet formulations is prednisolone, a related but different steroid. There are different "strength" steroid drugs, with different degrees of side effects; but, in general, a singe dose of steroids (e.g. an injection) is less likely to have side effects that a course (usually tablets).

David Harris BVSc MRCVS
MyVetMeds

Q. can colvasone be given to a dog with an infected anal gland
A.

As a powerful anti-inflammatory drug, it could be used as part of treatment, yes, at the discretion of the treating veterinary surgeon.

David Harris BVSc MRCVS
MyVetMeds

Q. how long does dexamethasone 1.5ml stay in a dogs stysem for
A.

Its quite variable between individuals; however, this product is generally short acting so I would usually expect a significant level to be in the system for about 2-3 days.

David Harris BVSc MRCVS
MyVetMeds

Q. Can I use colvasone for pregnant ewe who has had prolapse which is now retained she is about three weeks off lambing. 8paeH
A.

I would strongly advise you to seek advice from your own vet in this situation, as Colvasone is capable of inducing a late-term abortion, and potentially injuring the ewe further if not managed exactly right.

David Harris BVSc MRCVS
MyVetMeds

Q. my 12 year 0ld shih tzu died of liver cancer over the past 3 years my vet gave him a lot of dexamethasone injections 1.5ml for stomach upsets could this have caused this
A.

It is highly unlikely; dexamethasone isn't known to be a cancer-causing agent - it has a wide range of effects, and may worsen infections, cause changes in appetite and metabolism. However, there's no data that I am aware of that it can cause tumours to form in dogs at any dose rates.

David Harris BVSc MRCVS
MyVetMeds

Q. does the anrenal glands release dexamethasone daily
A.

The adrenal glands do not release dexamethasone, but cortisol and other steroid hormones, which are constantly being secreted at some level. Dexamethasone is a synthetic cortisol analogue.

David Harris BVSc MRCVS
MyVetMeds

Q. does the CREA test show the corticosteroid levels in a dogs blood
A.

No, CREA stands for Creatinine, which is a kidney function test.

David Harris BVSc MRCVS
MyVetMeds

Q. is it safe to give a shih tzu 2mg of dexamethasone for 7 days
A.

The dosage is very variable depending on the condition being treated, but that dose is not especially high for some inflammatory, shock-based or allergic conditions. Your vet will choose the dose based on the clinical presentation, and if you have any queries, you really should discuss it with them.

David Harris BVSc MRCVS
MyVetMeds

Q. what is heterogenous liver toumors is it primary or secornery cancer
A.

Heterogenous normally just refers to the appearance of the mass on ultrasound scan; it doesn't make any distinction between primary or secondary neoplasms. The only way to know what sort of tumour it is is to get a sample of it by biopsy.

David Harris BVSc MRCVS
MyVetMeds

Q. my dogs blood test is ALKP80 UL 23 212 . ALT 21 UL 10 100 IS THIS NORMAL
A.

That looks like the normal range for ALKP is 23-212, and it is 80 (and therefore normal), and ALT is 10-100, reading as 21 (normal).

David Harris BVSc MRCVS
MyVetMeds

Q. what is 1.5ml of colvasone in mg
A.

1.5ml of Colvasone contains 3mg of Dexamethasone.

David Harris BVSc MRCVS
MyVetMeds

Q. is 1.5 ml of colvasone safe for a shihtzu
A.

It depends how heavy he is! As a rule of thumb, the dose is 1ml per 10kg; however, in some clinical situations, higher doses are needed, so if your vet has prescribed or given a higher dose, it is probably because he or she felt that the dog required it on clinical grounds.
If you have a query, I would suggest you contatc your vet and ask them why they chose the dose they did.

David Harris BVSc MRCVS
MyVetMeds

Q. Is it safe to give a 30kg Cocker Spaniel 20ml of Colvasone in one injection?
A.

I'd say that generally, 3ml is the maximum you'd use in a dog of that size - however, the dose range for dexamethasone is very wide, and as an immunosuppresive dose, 15-20ml would be appropriate. Personally, I'd be inclined to separate it and inject at 2 sites, but there shouldn't be any problem if its already been done. I'd suggest you speak to your vet about it, and make sure they are aware of any concerns you may have. I would also say that you must follow the instructions of the prescribing vet - they know your dog, its history and medical status better than I can!

Hope that helps!

David Harris BVSc MRCVS
MyVetMeds

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