Delvosteron (20 ml)

Delvosteron (20 ml)
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The safety of progestagens is related to their molecular structure. Proligestone has a unique molecular configuration which makes it possible to administer Delvosteron at any stage of the oestrous cycle with little risk of undesirable effects on the endometrium.1. Oestrus control(i) BitchesPermanent... Read more
Delvosteron (20 ml)

The safety of progestagens is related to their molecular structure. Proligestone has a unique molecular configuration which makes it possible to administer Delvosteron at any stage of the oestrous cycle with little risk of undesirable effects on the endometrium.

1. Oestrus control

(i) Bitches

Permanent postponement of heat

Repeat injections given in anoestrus/metoestrus induced by the previous administration of Delvosteron.

Temporary postponement of heat

A single injection given in anoestrus.

Suppression of heat

A single injection given at the beginning of pro-oestrus.

(ii) Queens

Permanent postponement of calling

Repeat injections given in anoestrus/dioestrus induced by the previous administration of Delvosteron

Temporary postponement of calling

A single injection given during dioestrus or anoestrus.

Suppression of calling

A single injection given at the onset of calling.

(iii) Ferrets

To prevent problems such as vaginal and uterine infection and bone marrow depression associated with prolonged oestrus and persistently high oestrogen levels.

2. False pregnancy: treatment and prevention.

It has been shown that in most bitches, a single injection of Delvosteron will effectively alleviate both the nervous signs and lactation associated with false pregnancy. Trial results have indicated that the incidence of false pregnancy is markedly reduced following the use of Delvosteron for oestrus control irrespective of the bitch's previous history in respect of this condition.

3. Feline miliary dermatitis (miliary eczema): treatment and prevention.

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Product Description

About Delvosteron (20 ml)

Delvosteron (20 ml)

The safety of progestagens is related to their molecular structure. Proligestone has a unique molecular configuration which makes it possible to administer Delvosteron at any stage of the oestrous cycle with little risk of undesirable effects on the endometrium.

1. Oestrus control

(i) Bitches

Permanent postponement of heat

Repeat injections given in anoestrus/metoestrus induced by the previous administration of Delvosteron.

Temporary postponement of heat

A single injection given in anoestrus.

Suppression of heat

A single injection given at the beginning of pro-oestrus.

(ii) Queens

Permanent postponement of calling

Repeat injections given in anoestrus/dioestrus induced by the previous administration of Delvosteron

Temporary postponement of calling

A single injection given during dioestrus or anoestrus.

Suppression of calling

A single injection given at the onset of calling.

(iii) Ferrets

To prevent problems such as vaginal and uterine infection and bone marrow depression associated with prolonged oestrus and persistently high oestrogen levels.

2. False pregnancy: treatment and prevention.

It has been shown that in most bitches, a single injection of Delvosteron will effectively alleviate both the nervous signs and lactation associated with false pregnancy. Trial results have indicated that the incidence of false pregnancy is markedly reduced following the use of Delvosteron for oestrus control irrespective of the bitch's previous history in respect of this condition.

3. Feline miliary dermatitis (miliary eczema): treatment and prevention.

Please note: images are for illustration purposes only and pack sizes/strengths and new packaging styles may not be reflected in the image shown.

Directions For Use

Directions for Use

Dosage

Bitches: 10?33 mg/kg body weight. The recommended average doses are as follows:

Body weight (kg)


Dose in ml

<5


? 1?1.5

?5?10


1.5?2.5

10?20


2.5?3.5

20?30


3.5?4.5

30?45


4.5?5.5

45?60


5.5?6.0

thereafter


10 mg/kg

Cats: Oestrus control ? 1 ml for the average 3 kg cat. Feline miliary dermatitis ? 33?50 mg/kg, or 1.5 ml for the average 3 kg cat.

Ferrets: 0.5 ml per jill.

Route of administration

Delvosteron should be given by subcutaneous injection taking special care to ensure that the product is not deposited intradermally or into a pad of subcutaneous fat or scar tissue. The usual aseptic precautions should be observed, i.e. the site to be used should be cleansed and swabbed with spirit. It is helpful to massage the injection site following administration to promote dispersion of the product.

Dosage schedule

Bitches

Permanent postponement of heat

It is recommended that injections are given as follows:

1st injection
in pro-oestrus (see suppression of heat, overleaf), or in anoestrus (see temporary postponement of heat, overleaf).

2nd injection
3 months after 1st injection

3rd injection
4 months after 2nd injection

subsequent injections
at 5 month intervals.

An injection of Delvosteron may be given to maintain permanent postponement of heat in bitches that are presented late, provided that postponement has not been interrupted by heat.

If anoestrus is not fully maintained, i.e. a `breakthrough' oestrus occurs in bitches on the permanent postponement regime described above, then immediate re-injection is suggested followed by dosing at intervals described above, but starting one step back in the duration of intervals between injections. For example, if a breakthrough heat occurs in a bitch being given injections at 5 monthly intervals, an immediate dose is given, the next dose 4 months later and the subsequent doses at 5 monthly intervals.

Following termination of a permanent postponement course, the next oestrus will occur generally 6?7 months after the last injection. In approximately 4% of cases the interval may be less than 5 months and in 7% it may be longer than 12 months. Up to 3% of bitches may fail to come on heat again when a permanent postponement course is terminated.

Temporary postponement of heat

A single injection given at any time in anoestrus but preferably not more than one month before the effect is required. The subsequent oestrus will occur on average 6 months after the injection. In about 3% of cases the interval will be shorter than 3 months and in up to 4% of bitches the delay will be longer than 12 months.

Suppression of heat

A single injection as soon as possible after the onset of pro-oestrus is seen. Following the injection, bleeding, vulval swelling and attractiveness to dogs should gradually decrease and stop within 5?7 days. The time for return to oestrus in the majority of bitches will be 5?6 months on average, but in approximately 3% of bitches the interval will be shorter than 3 months and in 1% it will be longer than 12 months.

Treatment of false pregnancy

A single dose, given preferably as soon as the signs are seen. In most cases nervous signs will disappear within 6 days and lactation will have stopped or be much reduced by day 9 after injection. In approximately 20% of cases the signs will recur within one month of treatment, about 70% of these cases will respond to a second dose.

Prevention of false pregnancy

Medication for permanent postponement of oestrus as advocated above.

Queens

Oestrus control

Dosage regimes similar to those given for bitches are advised for permanent postponement, temporary postponement or the suppression of calling, except that for temporary postponement of calling the injections may be given in either dioestrus or anoestrus. Following injection at the onset of calling, the signs will usually abate within 1?4 days, but in a few cases such a response may not be seen for 7 days. As cats are seasonally polyoestrus, the recurrence of calling after treatment is very variable. However in one study 11% and 30% of cats called within 5 months after medication in anoestrus and pro-oestrus respectively. The return to calling will be further delayed if the non breeding season (anoestrus) intervenes.

Treatment and prevention of feline miliary dermatitis

A single injection is often sufficient but a second dose may be given 14 days later if the clinical response is not adequate. Dosing may need to be repeated every 4 months, or more frequently if necessary depending on the clinical response obtained.

Jills

Oestrus control

Delvosteron can be used to suppress or postpone heat in jills during the breeding season usually March to September. Following injection in jills showing prolonged oestrus (suppression) the signs will usually abate within 10?11 days. Injections given just before the onset of the breeding season (postponement) or during the breeding season (suppression or postponement) will usually maintain the jill in anoestrus for the remainder of the breeding season.

Active Ingredient

Delvosteron (20 ml) ingredients

A suspension for injection containing 100 mg/ml proligestone. Preservatives methylhydroxybenzoate 1 mg/ml and propylhydroxybenzoate 0.12 mg/ml.

Additional Data

Delvosteron (20 ml) specification

Specification: Detail:
Pack Size: 20 ml
Brands: Intervet
Product Form: injection

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Q & A

Q. I treated a bitch for postponement of heat, 2 weeks later she came on FULL heat. I injected a low dose1,5 ml for a small staffie. The owner informed me that she started bleeding 3-4 days ago. Can I still suppress the heat with delvosteron?
A.

As she's not responding as expected, I'd strongly advise you to contact the manufacturer for advice, but I'm afraid I'm not permitted to advise you further.

David Harris BVSc MRCVS
MyVetMeds

Q. we had our bitch injected at the onset of her season, one of our dogs has managed to escape and mate her 2 days after the injection, can you tell us how this injection will now effect her and if she is pregnant the puppies..
A.

The injection does reduce the probability that she's pregnant, but as its designed to stop her coming into season at all, and she did, there is a good chance she is, I'm afraid!
Assuming she has conceived, I wouldn't expect any damage to the puppies from this class of active ingredient, but I'm afraid to say as far as I'm aware, there isn't any test data available (for obvious reasons).
All I can suggest is that you contact your vet as soon as possible, and discuss ways to go forward.

David Harris BVSc MRCVS
MyVetMeds

Q. my dog just started showing begining heat ie.drops of blood on floor today. If I get the vet to inject delvosteron will this stop the heat and what signs should I look for..
A.

From the sound of it, she has just entered pro-oestrus; in this phase, Delvosterone with postpone but NOT prevent her fully coming into heat. I would strongly advise you to contact your vet and discuss the situation with them.

David Harris BVSc MRCVS
MyVetMeds

Q. We're looking for something we can put in the food of feral cats to prevent them from getting pregnant.

Does progestin come only in injectible form?
A.

Hi,

As far as I'm aware, the only oral contraceptive licensed for use in cats is Ovarid, in that it will postpone oestrus when used appropriately. As with Delvosterone, however, Ovarid does require a prescription from your vet.

Hope that helps,

David Harris BVSc MRCVS
MyVetMeds

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