Libromide Tablets for Dogs 325mg 500 tablets

Side effects of Libromide Tablets for Dogs 325mg 500 tablets

Special warnings for each target species
The concentration of bromide in serum, the clinical response and the therapeutic effect of administration of the product vary between individuals.
A high chloride intake can increase the elimination of bromide. Therefore, whilst it is not necessary for dogs receiving this product to be on a low salt diet, an increase in the dogs salt intake may require an adjustment in bromide dose. The salt content of a dogs diet during the treatment period should not be altered drastically, and should be maintained at a stable level. It is advisable not to change the dog?s diet during therapy.
Special precautions for use
i. Special precautions for use in animals.
Do not abruptly discontinue therapy as this may precipitate seizures.
This product should be used with caution in dogs with renal insufficiency.
A reduction in chloride intake could cause bromide intoxication.
ii. Special precautions for the person administering the veterinary medicinal product to animals.
This product can cause skin and eye-irritation. Avoid contact with the eyes. Wash hands thoroughly immediately after breaking or handling any tablets and before touching eyes. If the product comes in to contact with the eyes, rinse the eyes immediately with plenty of water and seek medical attention if irritation persists.
Do not handle this product if you are pregnant, think you are pregnant or if you are breast feeding.
Do not use this product if you have a known sensitivity to bromide.
Discontinue handling this product if you develop any signs of skin irritation, including itchiness, rash, peeling or flaking of skin or redness. Seek medical attention if irritation persists, showing the doctor this information.
If this product is ingested, seek medical attention as soon as possible, showing the doctor this information.
Advice to doctor: Bromide intoxication can be treated by administration of sodium chloride or a suitable chloruretic agent.
iii. Other precautions
None.
Adverse reactions
The most common side effects of bromide therapy are somnolence, ataxia (hind end weakness and loss of coordination), polyuria, polydipsia, nausea which may be accompanied by vomiting, pancreatitis and erythematous dermatitis (bromide rash).
A less common side effect of bromide therapy is behavioural changes such as irritability or restlessness.
Side effects may appear in dogs on higher doses of therapy, and symptoms usually disappear after the dose is decreased. If the dog appears too sedated, since the product is intended to be used as an adjunct therapy to phenobarbital, it may be preferable to decrease the phenobarbital dose rather than the bromide.
If potassium bromide dose is reduced, bromide serum concentrations should be monitored in order to ensure they fall within therapeutic range if seizures begin again.
Use during pregnancy, lactation or lay
Not for use in pregnant animals or nursing bitches.
Interactions
Bromide and chloride compete for re-absorption by the kidneys. A substantial increase in dietary chloride (salt) will cause decreased re-absorption of bromide by the kidneys. This means that if the amount of salt in the diet increases, bromide levels will decrease, which could lead to seizures. Conversely, switching to a diet low in chloride will cause bromide levels to increase, which could cause bromide intoxication.
Loop diuretics (e.g. furosemide) can increase bromide excretion and can lower the level of bromide in the blood.
Administration of fluids or drug formulations containing chloride would also be expected to lower serum bromide concentrations.

Overdose
Bromide toxicity is uncommon. It can occur in dogs with renal insufficiency or those that are on a very high dose of bromide. However, an overdose of this product can produce brominism, characterised by ataxia, somnolence, nausea and pancreatitis.
If overdose is suspected, the dosage of the product should be reduced immediately, with close monitoring of bromide serum concentrations in order to establish an appropriate therapeutic level.
In cases of overdose, if necessary and appropriate, 0.9% sodium chloride may be used intravenously to reduce serum bromide concentrations.