Norodine Granules 37.5 g (10 sachets)

Norodine Granules 37.5 g (10 sachets)
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For the treatment of bacterial infections in horses.Norodine is a broad-spectrum antibacterial, active against a wide range of Gram-positive and Gram-negative organisms. Together the active ingredients produce a double blockade of folinic acid synthesis in bacteria resulting in a level of activity much... Read more
Norodine Granules 37.5 g (10 sachets)

For the treatment of bacterial infections in horses.

Norodine is a broad-spectrum antibacterial, active against a wide range of Gram-positive and Gram-negative organisms. Together the active ingredients produce a double blockade of folinic acid synthesis in bacteria resulting in a level of activity much greater than that obtained from either drug alone.

In vitro Norodine is effective against Escherichia coli, Rhodococcus equi, Staphylococcus spp and Streptococcus spp.

When susceptible organisms are present Norodine Granules may be effective in treating the following conditions.

Alimentary tract infections including diarrhoea.

Respiratory tract infections including pneumonia, pleurisy and strangles.

Wounds, septicaemia and general infections.

Visit www.myvetmeds.co.uk / equine / antibiotics-equine / norodine-granules-37-5-g.htm

Product Description

About Norodine Granules 37.5 g (10 sachets)

Norodine Granules 37.5 g (10 sachets)

For the treatment of bacterial infections in horses.

Norodine is a broad-spectrum antibacterial, active against a wide range of Gram-positive and Gram-negative organisms. Together the active ingredients produce a double blockade of folinic acid synthesis in bacteria resulting in a level of activity much greater than that obtained from either drug alone.

In vitro Norodine is effective against Escherichia coli, Rhodococcus equi, Staphylococcus spp and Streptococcus spp.

When susceptible organisms are present Norodine Granules may be effective in treating the following conditions.

Alimentary tract infections including diarrhoea.

Respiratory tract infections including pneumonia, pleurisy and strangles.

Wounds, septicaemia and general infections.

Please note: images are for illustration purposes only and pack sizes/strengths and new packaging styles may not be reflected in the image shown.

Directions For Use

Directions for Use

Dosage:

The daily dose is 30 mg combined active ingredients per kg bodyweight (25 mg sulfadiazine and 5 mg trimethoprim per kg bodyweight). Each sachet contains one daily dose for a 500 kg horse.
DAILY DOSE
BODYWEIGHT Weight of Norodine Granules No. of Scoops
100 kg 7.5g 1/2
200 kg 15g 1
300 kg 22.5g 1 1/2
400 kg 30g 2
500 kg 37.5g Whole Sachet

Treatment should be continued for up to 5 days or until 2 days after symptoms have resolved.

The scoop provided dispenses 15g of granules.

Administration:

After careful estimation of the weight of the horse, the required dose of Norodine Granules should be mixed well with the horse's feed prior to administration.

Active Ingredient

Norodine Granules 37.5 g (10 sachets) ingredients

White to off-white granules with broad spectrum antibacterial activity. Presented in aluminium foil sachets. Norodine Granules are for oral administration to horses after mixing with feed. Each sachet contains 37.5 g of product containing: Trimethoprim Ph.Eur 2.5 g Sulphadiazine Ph.Eur 12.5 gWhite to off-white granules with broad-spectrum antibacterial activity. Presented in aluminium foil sachets. Norodine Granules are for oral administration to horses after mixing with feed. Each sachet contains 37.5 g of product containing:

Trimethoprim Ph.Eur. 2.5 g
Sulfadiazine Ph.Eur. 12.5 g

Side Effects

Side effects of Norodine Granules 37.5 g (10 sachets)

Do not use in horses intended for human consumption.

Do not use in horses with known sulphonamide sensitivity, with hepatic damage or with blood dyscrasias.

Avoid inhalation and direct contact with skin. Wash hands after use.

Additional Data

Norodine Granules 37.5 g (10 sachets) specification

Specification: Detail:
Pack Size: 10 sachets
Brands: Norbrook Laboratories
Product Form: granules
External Link:

http://www.norbrook.com/products/norodine-granules

Strength/Size: 37.5 g

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Q & A

Q. Hi
if the does is too high can this cause any problems? Thanks
A.

Excessive doses may increase the risk of side effects, but in general trimethoprim sulpha drugs (such as Norodine) are very safe.

David Harris BVSc MRCVS
MyVetMeds

Q. Can norodine be given to chickens for respiratory disease?
A.

It doesn't have a license for poultry, so any use would be on the cascade - i.e. there is no safety or efficacy data for it, so your vet would only prescribe it if they felt there was no other option.

David Harris BVSc MRCVS
MyVetMeds

Q. Helllo,
My TB mare sliced her tongue, its been stitched, all seems well, but
5 days into treatment with Norodine Granules she has swollen legs, rear are worse.
I did phone my vet and he said not to worry, turn her out and she will be fine.
2 days later and they are still swollen!
Please can you tell me why this happens and is it painful for my mare
Thank you
Sally Robinson
A.

It sounds like she's getting filled legs, which may be because of increased stabling, or a medical problem like lymphangitis. From what your vet has said, it doesn't sound like anything to worry about, but the easiest test is to push a finger into the swollen limb, and see if an imprint or impression remains afterwards. If so, you should call out your vet; otherwise, it may just be fluid building up because the mare's been stabled for longer than she's used to.
Filled legs is uncomfortable, but not painful, whereas lymphangitis is, or can be, acutely sore.
If in doubt, get her checked over by the vet!

David Harris BVSc MRCVS
MyVetMeds

Q. Can you feed norodine granules to a lactating mare?

she has given birth abouth a week ago, and had some skin irritation on her leg which I have been cleaning etc and her fetlock is a bit swollen so wandered if some dirt had gotten through the bad skin and caused the infection for swelling?
A.

The product is not licensed as safe in lactating mares, which means that the manufacturer hasn't tested it. The only data available on the safety of the active ingredients is from the datasheet for a different brand (Trimediazine):

"When administered to lactating females, small amounts of trimethoprim and sulfadiazine are present in the maternal milk. Since no studies have been reported on the effects of Trimediazine Plain on the development of new born foals, it would be prudent not to feed very young foals with milk obtained from mares being treated."

As a result, I wouldn't recommend it; however, your vet will be able to give you a better risk/benefit analysis in this particular case, and as Norodine is a prescription only medicine, I would strongly advise that you use it only under veterinary advice.

David Harris BVSc MRCVS
MyVetMeds

Q. Is Noradine safe to use with pregnant mares?
A.

There are no safety studies available for use and safety in pregnant mares, so I would advise against using it.

David Harris BVSc MRCVS
MyVetMeds

Q. What if your pony wont eat it?
A.

Most horses and ponies will eat the granules quite happily if they're mixed in with a bit of food - unlike bute, it doesn't have a nasty taste.
If your pony is unwilling to eat them all up, it might be worth mixing the granules in with a bit of molasses or treacle; hiding it in an apple; or if necessary, mixing it with water and syringing it into them like a wormer paste. Because this is an antibiotic, it is REALLY important that they get the whole dose every time, so if you're still having major problems/trouble, it might be worth contacting your vet to see if there's an alternative they can suggest.

David Harris BVSc MRCVS
MyVetMeds

Q. Can i dissolve in water before i put in my pony's feed.
A.

Yes, that's fine - when you think about it, it'll be dissolved in the stomach anyway, so as long as its fed immediately, there shouldn't be a problem.

David Harris BVSc MRCVS
MyVetMeds

Q. Can a pony be give a 10day course of 2 scahets a day, five days after course has finished another 15day course of 2 sachets a day due to an infection or would this be too much for a ponies sysyem?
A.

It depends on the infection and the size of the pony - for some diseases (like osteomyelitis), such high doses are often necessary; and for a heavy 14.2 it wouldn't be a problem.

Ultimately, your vet will have made the decision that this dose and frequency is necessary, and without knowing the case myself, I can't say whether its right or not. I can say that there are situations when its not just OK to use these doses, but actually necessary!

However, if you're concerned, I suggest you have a chat with your vet; meanwhile, make sure the pony has access to plenty of fresh water at all times, and keep an eye on his droppings to make sure they don't get too sloppy (this can be a warning sign of antibiotic problems).

I hope this helps,

David Harris BVSc MRCVS
MyVetMeds

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