Prascend Tablets 1mg (160 tablets)

Prascend Tablets 1mg (160 tablets)
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For the treatment of clinical signs associated with Pituitary Pars Intermedia Dysfunction, PPID (Equine Cushing’s Disease). Read more
Prascend Tablets 1mg (160 tablets)

For the treatment of clinical signs associated with Pituitary Pars Intermedia Dysfunction, PPID (Equine Cushing’s Disease).

Visit www.myvetmeds.co.uk / equine / hormones-equine / pergolide-tablets-250mcg.htm

Product Description

About Prascend Tablets 1mg (160 tablets)

Prascend Tablets 1mg (160 tablets)

For the treatment of clinical signs associated with Pituitary Pars Intermedia Dysfunction, PPID (Equine Cushing’s Disease).

Please note: images are for illustration purposes only and pack sizes/strengths and new packaging styles may not be reflected in the image shown.

Directions For Use

Directions for Use

dminister orally, once daily, at an average starting dose of 2 µg/kg bodyweight. Studies from the published literature cite the most common, average dose as 2 µg /kg with a range from 0.25 mg - 5 mg total daily dose per horse (0.6 – 10 µg/kg). The starting dose (2 µg/kg) should then be titrated according to the individual response as determined by monitoring (see below). Practical starting doses are recommended as follows:

 

Horse Body Weight

Starting Dose

Dosage Range

Number of Tablets

200 - 400 kg

0.5 mg

1.3 - 2.5 μg/kg

½

400 - 600 kg

1.0 mg

1.7 - 2.5 μg/kg

1

301 - 850 kg

1.5 mg

1.8 - 2.5 μg/kg

1 ½

851 - 1000 kg

2.0 mg

2.0 - 2.4 μg/kg

2

 

Tablets may be administered orally by dissolving the tablet with a small amount of water and/or mixing with molasses or other sweetener; taking care to rinse the dosing apparatus with water to ensure entire dose is administered; use immediately. Most horses respond to therapy and are stabilised at an average dose of 2 µg/kg. Clinical improvement with pergolide is expected within 6 to 12 weeks. Some horses may respond clinically at lower or varying doses, and it is recommended to titrate to the lowest effective dose per individual based on response to therapy, whether it is effectiveness or signs of intolerance. A small number of horses may require doses as high as 10 µg/kg per day. In these rare situations, appropriate additional monitoring should be implemented.

Monitoring and dose titration

Pre-treatment samples should be taken for appropriate diagnostic endocrinologic laboratory tests (e.g., serum or plasma ACTH or serum cortisol response to the low-dose dexamethasone suppression test) to diagnosis disease, monitor treatment, and for dose titration. Following initial diagnosis, repeat samples should be taken for endocrinologic testing for dose titration and monitoring of treatment at intervals of 6 weeks until stabilisation of clinical signs and/or diagnostic testing occurs. The approach to treatment is to titrate to the lowest effective dose per individual based on response to therapy, whether it is effectiveness or signs of intolerance. Dose titration is based on clinical sign improvement (e.g., hirsutism, polyuria, polydipsia, muscle wasting, abnormal fat distribution, chronic infections, etc.), and/or diagnostic testing improvement/normalisation (e.g., serum ACTH or serum cortisol response to the low-dose dexamethasone suppression test). Depending on the severity of the disease, time to treatment response may vary among individuals. For example, if clinical signs are not improving or if the diagnostic testing has not yet normalised at the first 6 week interval, the total daily dose may be increased by 0.5 mg. Some individuals may be improving but not yet normalised/stabilised and their dose may or may not need to be titrated based on the veterinarian’s discretion and the individual’s response/tolerance to the drug dose.Should clinical signs not be adequately controlled (based on clinical evaluation and/or diagnostic testing) consideration should be given to increasing the total daily dose by 0.5 mg increments every 6 weeks until stabilisation occurs and if the drug is tolerated at that dose. If signs of dose intolerance develop, treatment should be stopped for 2-3 days and reinstituted at one-half the previous dose. The total daily dose may be then be titrated back up to the desired clinical effect by 0.5 mg increments every 2-4 weeks. If a dose is missed, the next scheduled dose should be administered as prescribed. Following stabilisation, regular clinical assessment and diagnostic testing should occur every 6 months to monitor treatment and dose.

 


 

Active Ingredient

Prascend Tablets 1mg (160 tablets) ingredients

Tablet - Pink, modified rectangular shape scored tablet, engraved on one side the Boehringer Ingelheim logo and the letters “PRD” and contains 1.0 mg pergolide (as pergolide mesylate 1.31 mg)

Side Effects

Side effects of Prascend Tablets 1mg (160 tablets)

Warning:
Decreased appetite during the first week of treatment is the most commonly reported side effect of Pergolide. This may be managed by an initial reduced dose followed by a gradual increase.

Additional Data

Prascend Tablets 1mg (160 tablets) specification

Specification: Detail:
Pack Size: 160 tablets
Brands: Boehringer Ingelheim
Product Form: tablet
External Link:

http://www.noahcompendium.co.uk/boehringer_ingelheim_limited/documents/S6022.html

Reviews

How people have rated this so far

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34 years old
janet Vaughan on 3rd October 2013
* * * * -

OLPHIE HAS BEEN ON PRASCEND FOR SEVERAL YEARS, he has recently been prescribed 3 tablets a day, expensive but effective! He has gained weight with the addition of Top Spec Senior to his regular diet, looks well and is still interested in herd life. A little hairy in places but a lot better than last year. I have usually clipped and rugged him by end of Sept. he looks as if he has a more normal coat growth this Autumn. he is fed 3 times a day + grass + hay if he wants it. I am sure without Prascend I would have lost him in his 28th year. JV'

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Q & A

Q. My horse is on 3 Prascend a day, can I get the same dosage in 1 tablet?
A.

Unfortunately not - 1mg is the strongest form available!
There are weaker (250ug) ones on the human market (although your vets are legally obliged to prescribe the veterinary form of the drug if possible), but none stronger.

David Harris BVSc MRCVS
MyVetMeds

Q. What natural supplements can not be taken with pracend
A.

The manufacturers aren't aware of any major problems, but it does depend on which supplement you're planning to use, as they can't check every single one available on the market!

David Harris BVSc MRCVS
MyVetMeds

Q. Hi is the price listed on your website for Prascend inclusive of VAT or will VAT be added at the checkout as just trying to find cheapest option. Thanks
A.

All our prices include VAT, where applicable (Prascend is VAT liable, but that is included in the tablet- or box-price).

David Harris BVSc MRCVS
MyVetMeds

Q. My pony was tested for cushings early last year 2011, and was negative, but has ems, fat pads and fluid filled eye sockets. Her coat is fine.
She has had laminitas at least three times in the last 12 months, one slighly footy even, 2 full blown, both after worming! even though her diet is strictly controlled. During this last episode, she was pushed over the egde by Pramox wormer, (5 days after worming) and I could not get her condition to improve, 6 wks in. My vet wouldnt perscribe Prascend, however I managed to get hold of some through a friend. 3 days after giving her 1/2 a tablet, she was charging round her stable, 5 days in, walking on stones as thought nothing had ever been wrong. I am still confining her to the yard and managing her as there must be a fair amount of damage in her feet. She wasnt rooted to the spot, but was rocking from foot to foot .
Can it be, the fact she has improved so quickly, that she has cushings. I have been told the test is not always conclusive. I appriciate I should not self diagnose, however desperate measures etc. With her now stabalising, I am in a very awkward position, do I keep her on the drug, where can I get it, she will need monitoring, what should I do??

Kerry
A.

Hi,

I understand you have a bit of a problem there! The response to Prascend is suggestive of Cushings, but not necessarily diagnostic. There have been some reports of horses with advanced EMS responding to pergolide, so that may be what's going on.
There are a number of different blood tests for Cushings, and some are more accurate than others (usually, the most accurate ones aren't available to a "GP" vet, as they need specialised lab equipment).
My advice to you would be to "come clean" to your vet, for your pony's sake (!), and try and work with them to find out what's going on.
Remember, even if it is EMS not Cushings, there are treatments available that your vet can prescribe.

David Harris BVSc MRCVS
MyVetMeds

Q. my 16.2 thoroughbred x has just been diagnosed with cushings (the early stages) the vet has given me "prescend" at a dose of half a tablet once a day will this dosage be increased as the desease progresses or do you think i should hold off the tablets until she is showing more signs due to the effects that medication can have on the internal organs as we only did the blood test for cushings desease due to a slow recovery from an allergic reaction. hope this all makes sense thank you for your time nicola x
A.

Hi Nicola,

I'm sorry to hear about your horse.
Cushings is a very variable disease, and the degree to which horses respond to the medication is also variable. I've always found it best to take one step at a time, and modify the dose (up or down) according to the clinical picture and the blood test results. Some horses need enormous doses, and other stabilise on fractions of a tablet, so I really can't tell you how your is going to react!
Generally, we'd start on a highish dose, then reduce it down to the minimum necessary to control the disease. The dose required does tend to rise as the horse gets older, but it is quite slow.
Your vet knows your horse, so I would be guided by him/her at this stage. However, in my experience, the side effects at therapeutic doses are fairly minimal, and the benefits if you can control the disease at an early stage (for example, before the onset of laminitis) are huge.
Overall, I would suggest you have a chat with your vet if you're worried about side effects, but leaving it later to start treatment has its own risks as well!

Hope this helps,

David Harris BVSc MRCVS
MyVetMeds

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